Autonomic nervous system dysfunction in Parkinson's disease: relationships with age, medication, duration, and severity.
Identifieur interne : 001372 ( Main/Corpus ); précédent : 001371; suivant : 001373Autonomic nervous system dysfunction in Parkinson's disease: relationships with age, medication, duration, and severity.
Auteurs : J G Van Dijk ; J. Haan ; K. Zwinderman ; B. Kremer ; B J Van Hilten ; R A RoosSource :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 1993-10.
Abstract
Heart rate variability at rest, during deep breathing, or standing up and with the Valsalva manoeuvre did not differ significantly between 67 patients with idiopathic Parkinson's disease (PD) and 31 healthy age matched controls. Blood pressure (BP) responses to standing up and sustained handgrip revealed diminished autonomic function in the PD group. In a preliminary analysis of the PD group older age, anti-Parkinson medication and higher Hoehn and Yahr (HY) stages were each associated with poor autonomic responsiveness. Disease duration was only related to the systolic BP fall on standing up. Multiple stepwise regression analysis showed that older age explained most of the variance of heart rate variability (up to 36%), and the only significant PD related factor was the use of medication, which explained less than 7%. The HY stage accounted for 12.7% of the variance in the standing up BP test, and the use of medication explained 10.6% of the variance of the systolic BP change in the sustained hand grip test. The unmedicated PD subgroup (n = 33), who had mild disease of short duration, showed no evidence of autonomic dysfunction. Cardiovascular autonomic dysfunction in PD is mild, mainly affects blood pressure responses, and occurs only in advanced cases.
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DOI: 10.1136/jnnp.56.10.1090
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Zwinderman</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</mods:affiliation></affiliation></author><author><name sortKey="Kremer, B" sort="Kremer, B" uniqKey="Kremer B" first="B" last="Kremer">B. Kremer</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</mods:affiliation></affiliation></author><author><name sortKey="Van Hilten, B J" sort="Van Hilten, B J" uniqKey="Van Hilten B" first="B J" last="Van Hilten">B J Van Hilten</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</mods:affiliation></affiliation></author><author><name sortKey="Roos, R A" sort="Roos, R A" uniqKey="Roos R" first="R A" last="Roos">R A Roos</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E97EC409339424D58B5D8382AD25713FB078AF13</idno><date when="1993-10-01" year="1993">1993-10-01</date><idno type="doi">10.1136/jnnp.56.10.1090</idno><idno type="url">https://api.istex.fr/document/E97EC409339424D58B5D8382AD25713FB078AF13/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001372</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Autonomic nervous system dysfunction in Parkinson's disease: relationships with age, medication, duration, and severity.</title><author><name sortKey="Van Dijk, J G" sort="Van Dijk, J G" uniqKey="Van Dijk J" first="J G" last="Van Dijk">J G Van Dijk</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</mods:affiliation></affiliation></author><author><name sortKey="Haan, J" sort="Haan, J" uniqKey="Haan J" first="J" last="Haan">J. Haan</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</mods:affiliation></affiliation></author><author><name sortKey="Zwinderman, K" sort="Zwinderman, K" uniqKey="Zwinderman K" first="K" last="Zwinderman">K. Zwinderman</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</mods:affiliation></affiliation></author><author><name sortKey="Kremer, B" sort="Kremer, B" uniqKey="Kremer B" first="B" last="Kremer">B. Kremer</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</mods:affiliation></affiliation></author><author><name sortKey="Van Hilten, B J" sort="Van Hilten, B J" uniqKey="Van Hilten B" first="B J" last="Van Hilten">B J Van Hilten</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</mods:affiliation></affiliation></author><author><name sortKey="Roos, R A" sort="Roos, R A" uniqKey="Roos R" first="R A" last="Roos">R A Roos</name><affiliation><mods:affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="1993-10">1993-10</date><biblScope unit="volume">56</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1090">1090</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">E97EC409339424D58B5D8382AD25713FB078AF13</idno><idno type="DOI">10.1136/jnnp.56.10.1090</idno><idno type="href">jnnp-56-1090.pdf</idno><idno type="PMID">8410008</idno><idno type="local">jnnp;56/10/1090</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Heart rate variability at rest, during deep breathing, or standing up and with the Valsalva manoeuvre did not differ significantly between 67 patients with idiopathic Parkinson's disease (PD) and 31 healthy age matched controls. Blood pressure (BP) responses to standing up and sustained handgrip revealed diminished autonomic function in the PD group. In a preliminary analysis of the PD group older age, anti-Parkinson medication and higher Hoehn and Yahr (HY) stages were each associated with poor autonomic responsiveness. Disease duration was only related to the systolic BP fall on standing up. Multiple stepwise regression analysis showed that older age explained most of the variance of heart rate variability (up to 36%), and the only significant PD related factor was the use of medication, which explained less than 7%. The HY stage accounted for 12.7% of the variance in the standing up BP test, and the use of medication explained 10.6% of the variance of the systolic BP change in the sustained hand grip test. The unmedicated PD subgroup (n = 33), who had mild disease of short duration, showed no evidence of autonomic dysfunction. Cardiovascular autonomic dysfunction in PD is mild, mainly affects blood pressure responses, and occurs only in advanced cases.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>J G van Dijk</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</json:string></affiliations></json:item><json:item><name>J Haan</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</json:string></affiliations></json:item><json:item><name>K Zwinderman</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</json:string></affiliations></json:item><json:item><name>B Kremer</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</json:string></affiliations></json:item><json:item><name>B J van Hilten</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</json:string></affiliations></json:item><json:item><name>R A Roos</name><affiliations><json:string>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Research Article</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Heart rate variability at rest, during deep breathing, or standing up and with the Valsalva manoeuvre did not differ significantly between 67 patients with idiopathic Parkinson's disease (PD) and 31 healthy age matched controls. Blood pressure (BP) responses to standing up and sustained handgrip revealed diminished autonomic function in the PD group. In a preliminary analysis of the PD group older age, anti-Parkinson medication and higher Hoehn and Yahr (HY) stages were each associated with poor autonomic responsiveness. Disease duration was only related to the systolic BP fall on standing up. Multiple stepwise regression analysis showed that older age explained most of the variance of heart rate variability (up to 36%), and the only significant PD related factor was the use of medication, which explained less than 7%. The HY stage accounted for 12.7% of the variance in the standing up BP test, and the use of medication explained 10.6% of the variance of the systolic BP change in the sustained hand grip test. The unmedicated PD subgroup (n = 33), who had mild disease of short duration, showed no evidence of autonomic dysfunction. 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Blood pressure (BP) responses to standing up and sustained handgrip revealed diminished autonomic function in the PD group. In a preliminary analysis of the PD group older age, anti-Parkinson medication and higher Hoehn and Yahr (HY) stages were each associated with poor autonomic responsiveness. Disease duration was only related to the systolic BP fall on standing up. Multiple stepwise regression analysis showed that older age explained most of the variance of heart rate variability (up to 36%), and the only significant PD related factor was the use of medication, which explained less than 7%. The HY stage accounted for 12.7% of the variance in the standing up BP test, and the use of medication explained 10.6% of the variance of the systolic BP change in the sustained hand grip test. The unmedicated PD subgroup (n = 33), who had mild disease of short duration, showed no evidence of autonomic dysfunction. Cardiovascular autonomic dysfunction in PD is mild, mainly affects blood pressure responses, and occurs only in advanced cases.</p></abstract></profileDesc><revisionDesc><change when="1993-10-01">Created</change><change when="1993-10">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-3-14">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/E97EC409339424D58B5D8382AD25713FB078AF13/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article" xml:lang="EN"><front><journal-meta><journal-id journal-id-type="hwp">jnnp</journal-id><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-title>Journal of Neurology, Neurosurgery & Psychiatry</journal-title><abbrev-journal-title abbrev-type="publisher">J Neurol Neurosurg Psychiatry</abbrev-journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">8410008</article-id><article-id pub-id-type="other">jnnp;56/10/1090</article-id><article-id pub-id-type="doi">10.1136/jnnp.56.10.1090</article-id><article-id pub-id-type="other">1090</article-id><article-id pub-id-type="other">jnnp.56.10.1090</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Autonomic nervous system dysfunction in Parkinson's disease: relationships with age, medication, duration, and severity.</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>van Dijk</surname><given-names>J G</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Haan</surname><given-names>J</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Zwinderman</surname><given-names>K</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Kremer</surname><given-names>B</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>van Hilten</surname><given-names>B J</given-names></name></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Roos</surname><given-names>R A</given-names></name></contrib></contrib-group><aff>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</aff><pub-date pub-type="ppub"><month>10</month><year>1993</year></pub-date><pub-date pub-type="epub"><day>1</day><month>10</month><year>1993</year></pub-date><volume>56</volume><volume-id pub-id-type="other">56</volume-id><volume-id pub-id-type="other">56</volume-id><issue>10</issue><issue-id pub-id-type="other">jnnp;56/10</issue-id><issue-id pub-id-type="other">10</issue-id><issue-id pub-id-type="other">56/10</issue-id><fpage>1090</fpage><self-uri content-type="pdf" xlink:role="full-text" xlink:href="jnnp-56-1090.pdf"></self-uri><abstract><p>Heart rate variability at rest, during deep breathing, or standing up and with the Valsalva manoeuvre did not differ significantly between 67 patients with idiopathic Parkinson's disease (PD) and 31 healthy age matched controls. Blood pressure (BP) responses to standing up and sustained handgrip revealed diminished autonomic function in the PD group. In a preliminary analysis of the PD group older age, anti-Parkinson medication and higher Hoehn and Yahr (HY) stages were each associated with poor autonomic responsiveness. Disease duration was only related to the systolic BP fall on standing up. Multiple stepwise regression analysis showed that older age explained most of the variance of heart rate variability (up to 36%), and the only significant PD related factor was the use of medication, which explained less than 7%. The HY stage accounted for 12.7% of the variance in the standing up BP test, and the use of medication explained 10.6% of the variance of the systolic BP change in the sustained hand grip test. The unmedicated PD subgroup (n = 33), who had mild disease of short duration, showed no evidence of autonomic dysfunction. Cardiovascular autonomic dysfunction in PD is mild, mainly affects blood pressure responses, and occurs only in advanced cases.</p></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Autonomic nervous system dysfunction in Parkinson's disease: relationships with age, medication, duration, and severity.</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Autonomic nervous system dysfunction in Parkinson's disease: relationships with age, medication, duration, and severity.</title></titleInfo><name type="personal"><namePart type="given">J G</namePart><namePart type="family">van Dijk</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Haan</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Zwinderman</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Kremer</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B J</namePart><namePart type="family">van Hilten</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R A</namePart><namePart type="family">Roos</namePart><affiliation>Department of Neurology and Clinical Neurophysiology, University Hospital, Leiden, The Netherlands.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">1993-10</dateIssued><dateCreated encoding="w3cdtf">1993-10-01</dateCreated></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Heart rate variability at rest, during deep breathing, or standing up and with the Valsalva manoeuvre did not differ significantly between 67 patients with idiopathic Parkinson's disease (PD) and 31 healthy age matched controls. Blood pressure (BP) responses to standing up and sustained handgrip revealed diminished autonomic function in the PD group. In a preliminary analysis of the PD group older age, anti-Parkinson medication and higher Hoehn and Yahr (HY) stages were each associated with poor autonomic responsiveness. Disease duration was only related to the systolic BP fall on standing up. Multiple stepwise regression analysis showed that older age explained most of the variance of heart rate variability (up to 36%), and the only significant PD related factor was the use of medication, which explained less than 7%. The HY stage accounted for 12.7% of the variance in the standing up BP test, and the use of medication explained 10.6% of the variance of the systolic BP change in the sustained hand grip test. The unmedicated PD subgroup (n = 33), who had mild disease of short duration, showed no evidence of autonomic dysfunction. Cardiovascular autonomic dysfunction in PD is mild, mainly affects blood pressure responses, and occurs only in advanced cases.</abstract><relatedItem type="host"><titleInfo><title>Journal of Neurology, Neurosurgery & Psychiatry</title></titleInfo><titleInfo type="abbreviated"><title>J Neurol Neurosurg Psychiatry</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">0022-3050</identifier><identifier type="eISSN">1468-330X</identifier><identifier type="PublisherID-hwp">jnnp</identifier><identifier type="PublisherID-nlm-ta">J Neurol Neurosurg Psychiatry</identifier><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>56</number></detail><detail type="issue"><caption>no.</caption><number>10</number></detail><extent unit="pages"><start>1090</start></extent></part></relatedItem><identifier type="istex">E97EC409339424D58B5D8382AD25713FB078AF13</identifier><identifier type="DOI">10.1136/jnnp.56.10.1090</identifier><identifier type="href">jnnp-56-1090.pdf</identifier><identifier type="PMID">8410008</identifier><identifier type="local">jnnp;56/10/1090</identifier><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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